The pregnane X receptor down‐regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for (“squelching”) SRC‐1 coactivator

BACKGROUND AND PURPOSE: The organic cation transporter 1 (OCT1) transports cationic drugs into hepatocytes. The high hepatic expression of OCT1 is controlled by the HNF4α and USF transcription factors. Pregnane X receptor (PXR) mediates induction of the principal xenobiotic metabolizing enzymes and...

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Библиографические подробности
Опубликовано в: :Br J Pharmacol
Главные авторы: Hyrsova, Lucie, Smutny, Tomas, Carazo, Alejandro, Moravcik, Stefan, Mandikova, Jana, Trejtnar, Frantisek, Gerbal‐Chaloin, Sabine, Pavek, Petr
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2016
Предметы:
Research Papers
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4842917/
https://ncbi.nlm.nih.gov/pubmed/26920453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13472
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