The 3ʹ-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids

Pregnane X receptor (PXR) is the major regulator of xenobiotic metabolism. PXR itself is controlled by various signaling molecules including glucocorticoids. Moreover, negative feed-back regulation has been proposed at the transcriptional level. We examined the involvement of the 3′-untranslated reg...

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Bibliografske podrobnosti
izdano v:Acta Pharm Sin B
Main Authors: Smutny, Tomas, Dusek, Jan, Hyrsova, Lucie, Nekvindova, Jana, Horvatova, Alzbeta, Micuda, Stanislav, Gerbal-Chaloin, Sabine, Pavek, Petr
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2020
Teme:
Original article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6976988/
https://ncbi.nlm.nih.gov/pubmed/31998607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2019.09.010
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