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Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene
Metformin is widely used in the treatment of type-2 diabetes. The pleotropic effects of metformin on glucose and lipid metabolism have been proposed to be mediated by the activation of AMP-activated protein kinase (AMPK) and the subsequent up-regulation of small heterodimer partner (SHP). SHP suppre...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3205227/ https://ncbi.nlm.nih.gov/pubmed/21920351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2011.08.023 |
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