Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling

Phenobarbital is a central nervous system depressant that also indirectly activates nuclear receptor constitutive active androstane receptor (CAR), which promotes drug and energy metabolism, as well as cell growth (and death), in the liver. We found that phenobarbital activated CAR by inhibiting epi...

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Veröffentlicht in:Sci Signal
Hauptverfasser: Mutoh, Shingo, Sobhany, Mack, Moore, Rick, Perera, Lalith, Pedersen, Lee, Sueyoshi, Tatsuya, Negishi, Masahiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5573139/
https://ncbi.nlm.nih.gov/pubmed/23652203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2003705
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