Phosphorylated Nuclear Receptor CAR Forms a Homodimer To Repress Its Constitutive Activity for Ligand Activation

The nuclear receptor CAR (NR1I3) regulates hepatic drug and energy metabolism as well as cell fate. Its activation can be a critical factor in drug-induced toxicity and the development of diseases, including diabetes and tumors. CAR inactivates its constitutive activity by phosphorylation at threoni...

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Veröffentlicht in:Mol Cell Biol
Hauptverfasser: Shizu, Ryota, Osabe, Makoto, Perera, Lalith, Moore, Rick, Sueyoshi, Tatsuya, Negishi, Masahiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477554/
https://ncbi.nlm.nih.gov/pubmed/28265001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00649-16
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