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Ligand induced dissociation of the AR homodimer precedes AR monomer translocation to the nucleus
The androgen receptor (AR) regulates male sexual development. We have now investigated AR homodimerization, hormone-dependent monomerization and nuclear translocation in PC-3 and COS-1 cells, by utilizing mutations associated with the androgen insensitivity syndrome: Pro767Ala, Phe765Leu, Met743Val...
Enregistré dans:
| Publié dans: | Sci Rep |
|---|---|
| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6853983/ https://ncbi.nlm.nih.gov/pubmed/31723170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53139-9 |
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