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Active ERK1/2 Protein Interacts with the Phosphorylated Nuclear Constitutive Active/Androstane Receptor (CAR; NR1I3), Repressing Dephosphorylation and Sequestering CAR in the Cytoplasm

The nuclear constitutive active/androstane receptor (CAR) is inactivated and sequestered in the cytoplasm when Thr-38 is phosphorylated. Here, we have demonstrated that activated ERK1/2 interacts with phosphorylated CAR to repress dephosphorylation of Thr-38. The phosphorylation-dependent interactio...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Osabe, Makoto, Negishi, Masahiko
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195598/
https://ncbi.nlm.nih.gov/pubmed/21873423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.284596
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