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The Use of the LanthaScreen TR-FRET CAR Coactivator Assay in the Characterization of Constitutive Androstane Receptor (CAR) Inverse Agonists

The constitutive androstane receptor (CAR) is a critical nuclear receptor in the gene regulation of xenobiotic and endobiotic metabolism. The LanthaScreen(TM) TR-FRET CAR coactivator assay provides a simple and reliable method to analyze the affinity of a ligand to the human CAR ligand-binding domai...

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Detalhes bibliográficos
Publicado no:Sensors (Basel)
Main Authors: Carazo, Alejandro, Pávek, Petr
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4431184/
https://ncbi.nlm.nih.gov/pubmed/25905697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/s150409265
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