Gene-by-Environment Interaction of Bcrp(−/−) and Methionine- and Choline-Deficient Diet–Induced Nonalcoholic Steatohepatitis Alters SN-38 Disposition

Disease progression to nonalcoholic steatohepatitis (NASH) has profound effects on the expression and function of drug-metabolizing enzymes and transporters, which provide a mechanistic basis for variable drug response. Breast cancer resistance protein (BCRP), a biliary efflux transporter, exhibits...

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Detaylı Bibliyografya
Yayımlandı:Drug Metab Dispos
Asıl Yazarlar: Toth, Erica L., Li, Hui, Dzierlenga, Anika L., Clarke, John D., Vildhede, Anna, Goedken, Michael, Cherrington, Nathan J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2018
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6193212/
https://ncbi.nlm.nih.gov/pubmed/30166404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.118.082081
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