Effect of Nonalcoholic Steatohepatitis on Renal Filtration and Secretion of Adefovir

BACKGROUND & AIMS: Adefovir, an acyclic nucleotide reverse transcriptase inhibitor used to treat hepatitis B viral infection, is primarily eliminated renally through cooperation of glomerular filtration with active tubular transport. Nonalcoholic steatohepatitis is a variable in drug disposition...

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Publicat a:Biochem Pharmacol
Autors principals: Laho, Tomas, Clarke, John D., Dzierlenga, Anika L., Li, Hui, Klein, David M., Goedken, Michael, Micuda, Stanislav, Cherrington, Nathan J.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393628/
https://ncbi.nlm.nih.gov/pubmed/27381944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2016.07.001
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