In vivo cytochrome P450 activity alterations in diabetic nonalcoholic steatohepatitis mice

Nonalcoholic steatohepatitis (NASH) has been identified as a source of significant interindividual variation in drug metabolism. A previous ex vivo study demonstrated significant changes in hepatic Cytochrome P450 (CYP) activity in human NASH. This study evaluated the in vivo activities of multiple...

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Bibliographic Details
Published in:J Biochem Mol Toxicol
Main Authors: Li, Hui, Clarke, John D., Dzierlenga, Anika L., Bear, John, Goedken, Michael J., Cherrington, Nathan J.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5426479/
https://ncbi.nlm.nih.gov/pubmed/27712037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbt.21840
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