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Gene-by-Environment Interaction of Bcrp(−/−) and Methionine- and Choline-Deficient Diet–Induced Nonalcoholic Steatohepatitis Alters SN-38 Disposition
Disease progression to nonalcoholic steatohepatitis (NASH) has profound effects on the expression and function of drug-metabolizing enzymes and transporters, which provide a mechanistic basis for variable drug response. Breast cancer resistance protein (BCRP), a biliary efflux transporter, exhibits...
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| Vydáno v: | Drug Metab Dispos |
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| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The American Society for Pharmacology and Experimental Therapeutics
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6193212/ https://ncbi.nlm.nih.gov/pubmed/30166404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.118.082081 |
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