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NS6740, an α7 nicotinic acetylcholine receptor silent agonist, disrupts hippocampal synaptic plasticity

Long-term potentiation (LTP) in the dentate gyrus was previously shown to be enhanced by nicotine, an effect dependent on both homomeric α7 and heteromeric α2β2 nicotinic acetylcholine receptors (nAChR). In our experiments, bath-applied nicotine produced no significant enhancement of LTP. The α7 nAC...

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Detalhes bibliográficos
Publicado no:Neurosci Lett
Main Authors: Papke, Roger L., Peng, Can, Kumar, Ashok, Stokes, Clare
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6191859/
https://ncbi.nlm.nih.gov/pubmed/29679680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2018.04.025
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