Identification of α7 Nicotinic Acetylcholine Receptor Silent Agonists based on the Spirocyclic Quinuclidine-Δ(2)-Isoxazoline Scaffold: Synthesis and Electrophysiological Evaluation

Compound 11 (3-(benzyloxy)-1′-methyl-1′-azonia-4H-1′-azaspiro[isoxazole-5,3′-bicyclo[2.2.2]octane] iodide) was selected from a previous set of nicotinic ligands as a suitable model ligand for the design of new silent agonists of α7 nAChRs. Silent agonists evoke little or no channel activation but ca...

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Bibliographic Details
Published in:ChemMedChem
Main Authors: Quadri, Marta, Matera, Carlo, Silnović, Almin, Pismataro, Maria Chiara, Horenstein, Nicole A., Stokes, Clare, Papke, Roger L., Dallanoce, Clelia
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5573630/
https://ncbi.nlm.nih.gov/pubmed/28494140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700162
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