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Identification of α7 Nicotinic Acetylcholine Receptor Silent Agonists based on the Spirocyclic Quinuclidine-Δ(2)-Isoxazoline Scaffold: Synthesis and Electrophysiological Evaluation
Compound 11 (3-(benzyloxy)-1′-methyl-1′-azonia-4H-1′-azaspiro[isoxazole-5,3′-bicyclo[2.2.2]octane] iodide) was selected from a previous set of nicotinic ligands as a suitable model ligand for the design of new silent agonists of α7 nAChRs. Silent agonists evoke little or no channel activation but ca...
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| Publicat a: | ChemMedChem |
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| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5573630/ https://ncbi.nlm.nih.gov/pubmed/28494140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700162 |
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