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Epithelial Heparan Sulfate Contributes to Alveolar Barrier Function and Is Shed during Lung Injury

The lung epithelial glycocalyx is a carbohydrate-enriched layer lining the pulmonary epithelial surface. Although epithelial glycocalyx visualization has been reported, its composition and function remain unknown. Using immunofluorescence and mass spectrometry, we identified heparan sulfate (HS) and...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Haeger, Sarah M., Liu, Xinyue, Han, Xiaorui, McNeil, J. Brennan, Oshima, Kaori, McMurtry, Sarah A., Yang, Yimu, Ouyang, Yilan, Zhang, Fuming, Nozik-Grayck, Eva, Zemans, Rachel L., Tuder, Rubin M., Bastarache, Julie A., Linhardt, Robert J., Schmidt, Eric P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6189644/
https://ncbi.nlm.nih.gov/pubmed/29584451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2017-0428OC
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