Circulating heparan sulfate fragments mediate septic cognitive dysfunction

Septic patients frequently develop cognitive impairment that persists beyond hospital discharge. The impact of sepsis on electrophysiological and molecular determinants of learning is underexplored. We observed that mice that survived sepsis or endotoxemia experienced loss of hippocampal long-term p...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Hippensteel, Joseph A., Anderson, Brian J., Orfila, James E., McMurtry, Sarah A., Dietz, Robert M., Su, Guowei, Ford, Joshay A., Oshima, Kaori, Yang, Yimu, Zhang, Fuming, Han, Xiaorui, Yu, Yanlei, Liu, Jian, Linhardt, Robert J., Meyer, Nuala J., Herson, Paco S., Schmidt, Eric P.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2019
Sujets:
Concise Communication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436867/
https://ncbi.nlm.nih.gov/pubmed/30720464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI124485
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