Circulating heparan sulfate fragments mediate septic cognitive dysfunction

Septic patients frequently develop cognitive impairment that persists beyond hospital discharge. The impact of sepsis on electrophysiological and molecular determinants of learning is underexplored. We observed that mice that survived sepsis or endotoxemia experienced loss of hippocampal long-term p...

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Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: Hippensteel, Joseph A., Anderson, Brian J., Orfila, James E., McMurtry, Sarah A., Dietz, Robert M., Su, Guowei, Ford, Joshay A., Oshima, Kaori, Yang, Yimu, Zhang, Fuming, Han, Xiaorui, Yu, Yanlei, Liu, Jian, Linhardt, Robert J., Meyer, Nuala J., Herson, Paco S., Schmidt, Eric P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2019
Soggetti:
Concise Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436867/
https://ncbi.nlm.nih.gov/pubmed/30720464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI124485
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