Circulating heparan sulfate fragments mediate septic cognitive dysfunction

Septic patients frequently develop cognitive impairment that persists beyond hospital discharge. The impact of sepsis on electrophysiological and molecular determinants of learning is underexplored. We observed that mice that survived sepsis or endotoxemia experienced loss of hippocampal long-term p...

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Vydáno v:J Clin Invest
Hlavní autoři: Hippensteel, Joseph A., Anderson, Brian J., Orfila, James E., McMurtry, Sarah A., Dietz, Robert M., Su, Guowei, Ford, Joshay A., Oshima, Kaori, Yang, Yimu, Zhang, Fuming, Han, Xiaorui, Yu, Yanlei, Liu, Jian, Linhardt, Robert J., Meyer, Nuala J., Herson, Paco S., Schmidt, Eric P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
Témata:
Concise Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436867/
https://ncbi.nlm.nih.gov/pubmed/30720464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI124485
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