Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation

BACKGROUND: Intravenous fluids, an essential component of sepsis resuscitation, may paradoxically worsen outcomes by exacerbating endothelial injury. Preclinical models suggest that fluid resuscitation degrades the endothelial glycocalyx, a heparan sulfate-enriched structure necessary for vascular h...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Crit Care
Egile Nagusiak: Hippensteel, Joseph A., Uchimido, Ryo, Tyler, Patrick D., Burke, Ryan C., Han, Xiaorui, Zhang, Fuming, McMurtry, Sarah A., Colbert, James F., Lindsell, Christopher J., Angus, Derek C., Kellum, John A., Yealy, Donald M., Linhardt, Robert J., Shapiro, Nathan I., Schmidt, Eric P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2019
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6652002/
https://ncbi.nlm.nih.gov/pubmed/31337421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13054-019-2534-2
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