Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation

BACKGROUND: Intravenous fluids, an essential component of sepsis resuscitation, may paradoxically worsen outcomes by exacerbating endothelial injury. Preclinical models suggest that fluid resuscitation degrades the endothelial glycocalyx, a heparan sulfate-enriched structure necessary for vascular h...

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Detalles Bibliográficos
Publicado en:Crit Care
Main Authors: Hippensteel, Joseph A., Uchimido, Ryo, Tyler, Patrick D., Burke, Ryan C., Han, Xiaorui, Zhang, Fuming, McMurtry, Sarah A., Colbert, James F., Lindsell, Christopher J., Angus, Derek C., Kellum, John A., Yealy, Donald M., Linhardt, Robert J., Shapiro, Nathan I., Schmidt, Eric P.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2019
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6652002/
https://ncbi.nlm.nih.gov/pubmed/31337421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13054-019-2534-2
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