Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation

BACKGROUND: Intravenous fluids, an essential component of sepsis resuscitation, may paradoxically worsen outcomes by exacerbating endothelial injury. Preclinical models suggest that fluid resuscitation degrades the endothelial glycocalyx, a heparan sulfate-enriched structure necessary for vascular h...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Crit Care
Main Authors: Hippensteel, Joseph A., Uchimido, Ryo, Tyler, Patrick D., Burke, Ryan C., Han, Xiaorui, Zhang, Fuming, McMurtry, Sarah A., Colbert, James F., Lindsell, Christopher J., Angus, Derek C., Kellum, John A., Yealy, Donald M., Linhardt, Robert J., Shapiro, Nathan I., Schmidt, Eric P.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2019
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6652002/
https://ncbi.nlm.nih.gov/pubmed/31337421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13054-019-2534-2
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