Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation

BACKGROUND: Intravenous fluids, an essential component of sepsis resuscitation, may paradoxically worsen outcomes by exacerbating endothelial injury. Preclinical models suggest that fluid resuscitation degrades the endothelial glycocalyx, a heparan sulfate-enriched structure necessary for vascular h...

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Gepubliceerd in:Crit Care
Hoofdauteurs: Hippensteel, Joseph A., Uchimido, Ryo, Tyler, Patrick D., Burke, Ryan C., Han, Xiaorui, Zhang, Fuming, McMurtry, Sarah A., Colbert, James F., Lindsell, Christopher J., Angus, Derek C., Kellum, John A., Yealy, Donald M., Linhardt, Robert J., Shapiro, Nathan I., Schmidt, Eric P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2019
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6652002/
https://ncbi.nlm.nih.gov/pubmed/31337421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13054-019-2534-2
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