Circulating heparan sulfate fragments mediate septic cognitive dysfunction

Septic patients frequently develop cognitive impairment that persists beyond hospital discharge. The impact of sepsis on electrophysiological and molecular determinants of learning is underexplored. We observed that mice that survived sepsis or endotoxemia experienced loss of hippocampal long-term p...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Hippensteel, Joseph A., Anderson, Brian J., Orfila, James E., McMurtry, Sarah A., Dietz, Robert M., Su, Guowei, Ford, Joshay A., Oshima, Kaori, Yang, Yimu, Zhang, Fuming, Han, Xiaorui, Yu, Yanlei, Liu, Jian, Linhardt, Robert J., Meyer, Nuala J., Herson, Paco S., Schmidt, Eric P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Concise Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436867/
https://ncbi.nlm.nih.gov/pubmed/30720464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI124485
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