Dual Activation of Phosphodiesterases 3 and 4 Regulates Basal Spontaneous Beating Rate of Cardiac Pacemaker Cells: Role of Compartmentalization?

Spontaneous firing of sinoatrial (SA) node cells (SANCs) is regulated by cyclic adenosine monophosphate (cAMP)-mediated, protein kinase A (PKA)-dependent (cAMP/PKA) local subsarcolemmal Ca(2+) releases (LCRs) from ryanodine receptors (RyR). The LCRs occur during diastolic depolarization (DD) and act...

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Vydáno v:Front Physiol
Hlavní autoři: Vinogradova, Tatiana M., Kobrinsky, Evgeny, Lakatta, Edward G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Physiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6189467/
https://ncbi.nlm.nih.gov/pubmed/30356755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.01301
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