Dual Activation of Phosphodiesterases 3 and 4 Regulates Basal Spontaneous Beating Rate of Cardiac Pacemaker Cells: Role of Compartmentalization?

Spontaneous firing of sinoatrial (SA) node cells (SANCs) is regulated by cyclic adenosine monophosphate (cAMP)-mediated, protein kinase A (PKA)-dependent (cAMP/PKA) local subsarcolemmal Ca(2+) releases (LCRs) from ryanodine receptors (RyR). The LCRs occur during diastolic depolarization (DD) and act...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Vinogradova, Tatiana M., Kobrinsky, Evgeny, Lakatta, Edward G.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6189467/
https://ncbi.nlm.nih.gov/pubmed/30356755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.01301
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