Sarcoplasmic reticulum Ca(2+) pumping kinetics regulates timing of local Ca(2+) releases and spontaneous beating rate of rabbit sinoatrial node pacemaker cells

RATIONALE: Sinoatrial node cells (SANC) generate local, subsarcolemmal Ca(2+) releases (LCRs) from sarcoplasmic reticulum (SR) during late diastolic depolarization (DD). LCRs activate an inward Na(+)-Ca(2+) exchange current (I(NCX)) which accelerates DD rate, prompting the next action potential (AP)...

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Detalhes bibliográficos
Main Authors: Vinogradova, Tatiana M., Brochet, Didier, Sirenko, Syevda, Li, Yue, Spurgeon, Harold, Lakatta, Edward G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2941556/
https://ncbi.nlm.nih.gov/pubmed/20651285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.110.220517
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