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Stochasticity intrinsic to coupled-clock mechanisms underlies beat-to-beat variability of spontaneous action potential firing in sinoatrial node pacemaker cells: Unified regulation of sinoatrial node pacemaker cell beating rate and rhythm
Recent evidence indicates that the spontaneous action potential (AP) of isolated sinoatrial node cells (SANC) is regulated by a system of stochastic mechanisms embodied within two clocks: ryanodine receptors of the “Ca(2+) clock” within the sarcoplasmic reticulum, spontaneously activate during diast...
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| Pubblicato in: | J Mol Cell Cardiol |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4312254/ https://ncbi.nlm.nih.gov/pubmed/25257916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2014.09.008 |
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