Stochasticity intrinsic to coupled-clock mechanisms underlies beat-to-beat variability of spontaneous action potential firing in sinoatrial node pacemaker cells: Unified regulation of sinoatrial node pacemaker cell beating rate and rhythm

Recent evidence indicates that the spontaneous action potential (AP) of isolated sinoatrial node cells (SANC) is regulated by a system of stochastic mechanisms embodied within two clocks: ryanodine receptors of the “Ca(2+) clock” within the sarcoplasmic reticulum, spontaneously activate during diast...

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Detalhes bibliográficos
Publicado no:J Mol Cell Cardiol
Main Authors: Yaniv, Yael, Lyashkov, Alexey E., Sirenko, Syevda, Okamoto, Yosuke, Guiriba, Toni-Rose, Ziman, Bruce D., Morrell, Christopher H., Lakatta, Edward G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4312254/
https://ncbi.nlm.nih.gov/pubmed/25257916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2014.09.008
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