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Sarcoplasmic Reticulum Ca(2+) Cycling Protein Phosphorylation in a Physiologic Ca(2+) Milieu Unleashes a High-Power, Rhythmic Ca(2+) Clock in Ventricular Myocytes: Relevance to Arrhythmias and Bio-Pacemaker Design
Basal phosphorylation of sarcoplasmic reticulum (SR) Ca(2+) proteins is high in sinoatrial nodal cells (SANC), which generate partially synchronized, spontaneous, rhythmic, diastolic local Ca(2+) releases (LCRs), but low in ventricular myocytes (VM), which exhibit rare diastolic, stochastic SR-gener...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3896924/ https://ncbi.nlm.nih.gov/pubmed/24274954 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2013.11.011 |
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