Sarcoplasmic Reticulum Ca(2+) Cycling Protein Phosphorylation in a Physiologic Ca(2+) Milieu Unleashes a High-Power, Rhythmic Ca(2+) Clock in Ventricular Myocytes: Relevance to Arrhythmias and Bio-Pacemaker Design

Basal phosphorylation of sarcoplasmic reticulum (SR) Ca(2+) proteins is high in sinoatrial nodal cells (SANC), which generate partially synchronized, spontaneous, rhythmic, diastolic local Ca(2+) releases (LCRs), but low in ventricular myocytes (VM), which exhibit rare diastolic, stochastic SR-gener...

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Detalhes bibliográficos
Main Authors: Sirenko, Syevda, Maltsev, Victor A, Maltseva, Larissa A, Yang, Dongmei, Lukyanenko, Yevgeniya, Vinogradova, Tatiana, Jones, Larry, Lakatta, Edward G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896924/
https://ncbi.nlm.nih.gov/pubmed/24274954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2013.11.011
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