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Synchronization of Stochastic Ca(2+) Release Units Creates a Rhythmic Ca(2+) Clock in Cardiac Pacemaker Cells

In sinoatrial node cells of the heart, beating rate is controlled, in part, by local Ca(2+) releases (LCRs) from the sarcoplasmic reticulum, which couple to the action potential via electrogenic Na(+)/Ca(2+) exchange. We observed persisting, roughly periodic LCRs in depolarized rabbit sinoatrial nod...

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Bibliographische Detailangaben
Hauptverfasser: Maltsev, Anna V., Maltsev, Victor A., Mikheev, Maxim, Maltseva, Larissa A., Sirenko, Syevda G., Lakatta, Edward G., Stern, Michael D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2011
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021664/
https://ncbi.nlm.nih.gov/pubmed/21244823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.11.081
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