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Synchronization of Stochastic Ca(2+) Release Units Creates a Rhythmic Ca(2+) Clock in Cardiac Pacemaker Cells
In sinoatrial node cells of the heart, beating rate is controlled, in part, by local Ca(2+) releases (LCRs) from the sarcoplasmic reticulum, which couple to the action potential via electrogenic Na(+)/Ca(2+) exchange. We observed persisting, roughly periodic LCRs in depolarized rabbit sinoatrial nod...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Biophysical Society
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3021664/ https://ncbi.nlm.nih.gov/pubmed/21244823 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.11.081 |
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