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Synergism of coupled subsarcolemmal Ca(2+) clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model

Recent experimental studies have demonstrated that sinoatrial node cells (SANC) generate spontaneous, rhythmic, local subsarcolemmal Ca(2+) releases (Ca(2+) clock), which occur during late diastolic depolarization (DD) and interact with the classic sarcolemmal voltage oscillator (membrane clock) by...

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Bibliografiske detaljer
Main Authors: Maltsev, Victor A., Lakatta, Edward G.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2660239/
https://ncbi.nlm.nih.gov/pubmed/19136600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01118.2008
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