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Numerical models based on a minimal set of sarcolemmal electrogenic proteins and an intracellular Ca(2+) clock generate robust, flexible, and energy-efficient cardiac pacemaking
Recent evidence supports the idea that robust and, importantly, FLEXIBLE automaticity of cardiac pacemaker cells is conferred by a coupled system of membrane ion currents (an “M-clock”) and a sarcoplasmic reticulum (SR)-based Ca(2+) oscillator (“Ca(2+)clock”) that generates spontaneous diastolic Ca(...
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| Publicado no: | J Mol Cell Cardiol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4538696/ https://ncbi.nlm.nih.gov/pubmed/23507256 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2013.03.004 |
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