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A coupled SYSTEM of intracellular Ca(2+) clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart’s pacemaker

Ion channels on the surface membrane of sinoatrial nodal pacemaker cells (SANC) are the proximal cause of an action potential. Each individual channel type has been thoroughly characterized under voltage clamp, and the ensemble of the ion channel currents reconstructed in silico generates rhythmic a...

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Detalhes bibliográficos
Main Authors: Lakatta, Edward G., Maltsev, Victor A., Vinogradova, Tatiana M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837285/
https://ncbi.nlm.nih.gov/pubmed/20203315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.206078
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