A coupled SYSTEM of intracellular Ca(2+) clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart’s pacemaker

Eitemau Tebyg

• Synergism of coupled subsarcolemmal Ca(2+) clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model
  gan: Maltsev, Victor A., et al.
  Cyhoeddwyd: (2009)
• Letter to the editor: “Validating the requirement for beat-to-beat coupling of the Ca(2+) clock and M clock in pacemaker cell normal automaticity”
  gan: Maltsev, Victor A., et al.
  Cyhoeddwyd: (2011)
• Normal heart rhythm is initiated and regulated by an intracellular Calcium clock within pacemaker cells
  gan: Maltsev, Victor A., et al.
  Cyhoeddwyd: (2007)
• The funny current in the context of the coupled clock pacemaker cell system
  gan: Maltsev, Victor A., et al.
  Cyhoeddwyd: (2011)
• New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: bradycardic effects of ivabradine are linked to suppression of intracellular Ca(2+) cycling: Dual effects of ivabradine on Ca(2+) and membrane clocks
  gan: Yaniv, Yael, et al.
  Cyhoeddwyd: (2013)