CaMKII-dependent phosphorylation regulates basal cardiac pacemaker function via modulation of local Ca(2+) releases

Spontaneous beating of the heart pacemaker, the sinoatrial node, is generated by sinoatrial node cells (SANC) due to gradual change of the membrane potential called diastolic depolarization (DD). Spontaneous, submembrane local Ca(2+) releases (LCR) from ryanodine receptors (RyR) occur during late DD...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Li, Yue, Sirenko, Syevda, Riordon, Daniel R., Yang, Dongmei, Spurgeon, Harold, Lakatta, Edward G., Vinogradova, Tatiana M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2016
Assuntos:
Cardiac Excitation and Contraction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142178/
https://ncbi.nlm.nih.gov/pubmed/27402669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00765.2015
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