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Crosstalk between Mitochondrial and Sarcoplasmic Reticulum Ca(2+) Cycling Modulates Cardiac Pacemaker Cell Automaticity
BACKGROUND: Mitochondria dynamically buffer cytosolic Ca(2+) in cardiac ventricular cells and this affects the Ca(2+) load of the sarcoplasmic reticulum (SR). In sinoatrial-node cells (SANC) the SR generates periodic local, subsarcolemmal Ca(2+) releases (LCRs) that depend upon the SR load and are i...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3362629/ https://ncbi.nlm.nih.gov/pubmed/22666369 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037582 |
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