Crosstalk between Mitochondrial and Sarcoplasmic Reticulum Ca(2+) Cycling Modulates Cardiac Pacemaker Cell Automaticity

BACKGROUND: Mitochondria dynamically buffer cytosolic Ca(2+) in cardiac ventricular cells and this affects the Ca(2+) load of the sarcoplasmic reticulum (SR). In sinoatrial-node cells (SANC) the SR generates periodic local, subsarcolemmal Ca(2+) releases (LCRs) that depend upon the SR load and are i...

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Detalhes bibliográficos
Main Authors: Yaniv, Yael, Spurgeon, Harold A., Lyashkov, Alexey E., Yang, Dongmei, Ziman, Bruce D., Maltsev, Victor A., Lakatta, Edward G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362629/
https://ncbi.nlm.nih.gov/pubmed/22666369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037582
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