Mechanisms that match ATP supply to demand in cardiac pacemaker cells during high ATP demand

The spontaneous action potential (AP) firing rate of sinoatrial node cells (SANCs) involves high-throughput signaling via Ca(2+)-calmodulin activated adenylyl cyclases (AC), cAMP-mediated protein kinase A (PKA), and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-dependent phosphorylation of...

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Hauptverfasser: Yaniv, Yael, Spurgeon, Harold A., Ziman, Bruce D., Lyashkov, Alexey E., Lakatta, Edward G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2013
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680726/
https://ncbi.nlm.nih.gov/pubmed/23604710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00969.2012
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