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Unique Ca(2+)-Cycling Protein Abundance and Regulation Sustains Local Ca(2+) Releases and Spontaneous Firing of Rabbit Sinoatrial Node Cells

Spontaneous beating of the heart pacemaker, the sinoatrial node, is generated by sinoatrial node cells (SANC) and caused by gradual change of the membrane potential called diastolic depolarization (DD). Submembrane local Ca(2+) releases (LCR) from sarcoplasmic reticulum (SR) occur during late DD and...

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Bibliographische Detailangaben
Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Vinogradova, Tatiana M., Tagirova (Sirenko), Syevda, Lakatta, Edward G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6121616/
https://ncbi.nlm.nih.gov/pubmed/30044420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19082173
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