Basal Spontaneous Firing of Rabbit Sinoatrial Node Cells is Regulated by Dual Phosphodiesterase 3 and 4 Activation

BACKGROUND: Spontaneous firing of sinoatrial node cells (SANC) is regulated by cAMP-mediated, PKA-dependent (cAMP/PKA) local subsarcolemmal Ca(2+) releases (LCRs) from ryanodine receptors (RyR). LCRs occur during diastolic depolarization (DD) and activate an inward Na(+)/Ca(2+) exchange current that...

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Detalhes bibliográficos
Publicado no:Circ Arrhythm Electrophysiol
Main Authors: Vinogradova, Tatiana M., Sirenko, Syevda, Lukyanenko, Yevgeniya O., Yang, Dongmei, Tarasov, Kirill V., Lyashkov, Alexey E., Varghese, Nevin J., Li, Yue, Chakir, Khalid, Ziman, Bruce, Lakatta, Edward G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6025775/
https://ncbi.nlm.nih.gov/pubmed/29880528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.117.005896
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