Ca(2+)/calmodulin-activated phosphodiesterase 1A is highly expressed in rabbit cardiac sinoatrial nodal cells and regulates pacemaker function

Constitutive Ca(2+)/calmodulin (CaM)-activation of adenylyl cyclases (ACs) types 1 and 8 in sinoatrial nodal cells (SANC) generates cAMP within lipid-raft-rich microdomains to initiate cAMP–protein kinase A (PKA) signaling, that regulates basal state rhythmic action potential firing of these cells....

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Détails bibliographiques
Publié dans:J Mol Cell Cardiol
Auteurs principaux: Lukyanenko, Yevgeniya O., Younes, Antoine, Lyashkov, Alexey E., Tarasov, Kirill V., Riordon, Daniel R., Lee, Joonho, Sirenko, Syevda G., Kobrinsky, Evgeny, Ziman, Bruce, Tarasova, Yelena S., Juhaszova, Magdalena, Sollott, Steven J., Graham, David R., Lakatta, Edward G.
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5054686/
https://ncbi.nlm.nih.gov/pubmed/27363295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2016.06.064
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