Impact of Variable RNA-Sequencing Depth on Gene Expression Signatures and Target Compound Robustness: Case Study Examining Brain Tumor (Glioma) Disease Progression

PURPOSE: Gene expression profiling can uncover biologic mechanisms underlying disease and is important in drug development. RNA sequencing (RNA-seq) is routinely used to assess gene expression, but costs remain high. Sample multiplexing reduces RNA-seq costs; however, multiplexed samples have lower...

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Detalhes bibliográficos
Publicado no:JCO Precis Oncol
Main Authors: Stupnikov, Alexey, O’Reilly, Paul G., McInerney, Caitriona E., Roddy, Aideen C., Dunne, Philip D., Gilmore, Alan, Ellis, Hayley P., Flannery, Tom, Healy, Estelle, McIntosh, Stuart A., Savage, Kienan, Kurian, Kathreena M., Emmert-Streib, Frank, Prise, Kevin M., Salto-Tellez, Manuel, McArt, Darragh G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2018
Assuntos:
Original Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6186166/
https://ncbi.nlm.nih.gov/pubmed/30324181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.18.00014
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