P04.46 Variable RNA sequencing depth impacts gene signatures and target compound robustness - case study examining brain tumour (glioma) disease progression

BACKGROUND: Gene expression profiling can uncover biological mechanisms underlying disease and is important in drug development. RNA-seq is routinely used to assess gene expression but costs remain high. Sample multiplexing reduces RNA-seq costs, however, multiplexed samples have lower cDNA sequenci...

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Bibliographische Detailangaben
Veröffentlicht in:Neuro Oncol
Hauptverfasser: Stupnikov, A, McInerney, C E, O’Reilly, P G, Roddy, A C, Dunne, P D, Gilmore, A, Savage, K, McIntosh, S A, Flannery, T, Healy, E, Ellis, H P, Kurian, K M, Emmert-Streib, F, Prise, K M, Salto-Tellez, M, McArt, D G
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
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Poster Presentations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6144694/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy139.280
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