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Towards New Antibiotics Targeting Bacterial Transglycosylase: Synthesis of a Lipid II Analog as Stable Transition-State Mimic Inhibitor
Described here is the asymmetric synthesis of iminosugar 2b, a Lipid II analog, designed to mimic the transition state of transglycosylation catalyzed by the bacterial transglycosylase. The high density of functional groups, together with a rich stereochemistry, represents an extraordinary challenge...
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| Udgivet i: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6182773/ https://ncbi.nlm.nih.gov/pubmed/29602680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.03.035 |
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