Domain requirement of moenomycin binding to bifunctional transglycosylases and development of high-throughput discovery of antibiotics

Moenomycin inhibits bacterial growth by blocking the transglycosylase activity of class A penicillin-binding proteins (PBPs), which are key enzymes in bacterial cell wall synthesis. We compared the binding affinities of moenomycin A with various truncated PBPs by using surface plasmon resonance anal...

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Hauptverfasser: Cheng, Ting-Jen Rachel, Sung, Ming-Ta, Liao, Hsin-Yu, Chang, Yi-Fan, Chen, Chia-Wei, Huang, Chia-Ying, Chou, Lien-Yang, Wu, Yen-Da, Chen, Yin-Hsuan, Cheng, Yih-Shyun E., Wong, Chi-Huey, Ma, Che, Cheng, Wei-Chieh
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Physical Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206553/
https://ncbi.nlm.nih.gov/pubmed/18182485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710868105
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