Optimization of fermentation conditions for an Escherichia coli strain engineered using the response surface method to produce a novel therapeutic DNA vaccine for rheumatoid arthritis

BACKGROUND: Fermentation condition optimization and nutrients screening are of equal importance for efficient production of plasmid DNA vaccines. This directly affects the downstream purification and final quality and yield of plasmid DNA vaccines. The present study aimed to optimize the fermentatio...

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Detalhes bibliográficos
Publicado no:J Biol Eng
Main Authors: Long, Juan, Zhao, Xiao, Liang, Fei, Liu, Nan, Sun, Yuying, Xi, Yongzhi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6180442/
https://ncbi.nlm.nih.gov/pubmed/30337953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13036-018-0110-y
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