Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of Mycobacterium tuberculosis

New drugs are needed to control the current tuberculosis (TB) pandemic caused by infection with Mycobacterium tuberculosis. We report here on our work with AX-35, an arylvinylpiperazine amide, and four related analogs, which are potent antitubercular agents in vitro. All five compounds showed good a...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Foo, Caroline S., Lupien, Andréanne, Kienle, Maryline, Vocat, Anthony, Benjak, Andrej, Sommer, Raphael, Lamprecht, Dirk A., Steyn, Adrie J. C., Pethe, Kevin, Piton, Jérémie, Altmann, Karl-Heinz, Cole, Stewart T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6178619/
https://ncbi.nlm.nih.gov/pubmed/30301850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01276-18
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