New 2-Ethylthio-4-methylaminoquinazoline derivatives inhibiting two subunits of cytochrome bc1 in Mycobacterium tuberculosis

The emergence of multi-drug (MDR-TB) and extensively-drug resistant tuberculosis (XDR-TB) is a major threat to the global management of tuberculosis (TB) worldwide. New chemical entities are of need to treat drug-resistant TB. In this study, the mode of action of new, potent quinazoline derivatives...

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Publicat a:PLoS Pathog
Autors principals: Lupien, Andréanne, Foo, Caroline Shi-Yan, Savina, Svetlana, Vocat, Anthony, Piton, Jérémie, Monakhova, Natalia, Benjak, Andrej, Lamprecht, Dirk A., Steyn, Adrie J. C., Pethe, Kevin, Makarov, Vadim A., Cole, Stewart T.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6999911/
https://ncbi.nlm.nih.gov/pubmed/31971990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008270
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