Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of Mycobacterium tuberculosis

New drugs are needed to control the current tuberculosis (TB) pandemic caused by infection with Mycobacterium tuberculosis. We report here on our work with AX-35, an arylvinylpiperazine amide, and four related analogs, which are potent antitubercular agents in vitro. All five compounds showed good a...

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Dettagli Bibliografici
Pubblicato in:mBio
Autori principali: Foo, Caroline S., Lupien, Andréanne, Kienle, Maryline, Vocat, Anthony, Benjak, Andrej, Sommer, Raphael, Lamprecht, Dirk A., Steyn, Adrie J. C., Pethe, Kevin, Piton, Jérémie, Altmann, Karl-Heinz, Cole, Stewart T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6178619/
https://ncbi.nlm.nih.gov/pubmed/30301850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01276-18
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