Improved Phenoxyalkylbenzimidazoles with Activity against Mycobacterium tuberculosis Appear to Target QcrB

[Image: see text] The phenoxy alkyl benzimidazoles (PABs) have good antitubercular activity. We expanded our structure–activity relationship studies to determine the core components of PABs required for activity. The most potent compounds had minimum inhibitory concentrations against Mycobacterium t...

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Detalhes bibliográficos
Publicado no:ACS Infect Dis
Main Authors: Chandrasekera, N. Susantha, Berube, Bryan J., Shetye, Gauri, Chettiar, Somsundaram, O’Malley, Theresa, Manning, Alyssa, Flint, Lindsay, Awasthi, Divya, Ioerger, Thomas R., Sacchettini, James, Masquelin, Thierry, Hipskind, Philip A., Odingo, Joshua, Parish, Tanya
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727484/
https://ncbi.nlm.nih.gov/pubmed/29035551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.7b00112
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