Improved Phenoxyalkylbenzimidazoles with Activity against Mycobacterium tuberculosis Appear to Target QcrB

[Image: see text] The phenoxy alkyl benzimidazoles (PABs) have good antitubercular activity. We expanded our structure–activity relationship studies to determine the core components of PABs required for activity. The most potent compounds had minimum inhibitory concentrations against Mycobacterium t...

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Veröffentlicht in:ACS Infect Dis
Hauptverfasser: Chandrasekera, N. Susantha, Berube, Bryan J., Shetye, Gauri, Chettiar, Somsundaram, O’Malley, Theresa, Manning, Alyssa, Flint, Lindsay, Awasthi, Divya, Ioerger, Thomas R., Sacchettini, James, Masquelin, Thierry, Hipskind, Philip A., Odingo, Joshua, Parish, Tanya
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2017
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727484/
https://ncbi.nlm.nih.gov/pubmed/29035551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.7b00112
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