Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming

The NLRP3 inflammasome is an important regulator of inflammation and immunity. It is a multimolecular platform formed within cells that facilitates the activation of proinflammatory caspases to drive secretion of cytokines such as interleukin-1β (IL-1β). Knowledge of the mechanisms regulating format...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Green, Jack P., Yu, Shi, Martín-Sánchez, Fátima, Pelegrin, Pablo, Lopez-Castejon, Gloria, Lawrence, Catherine B., Brough, David
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6176575/
https://ncbi.nlm.nih.gov/pubmed/30232264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1812744115
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