Phenotype-Specific Enrichment of Mendelian Disorder Genes near GWAS Regions across 62 Complex Traits

Although recent studies provide evidence for a common genetic basis between complex traits and Mendelian disorders, a thorough quantification of their overlap in a phenotype-specific manner remains elusive. Here, we have quantified the overlap of genes identified through large-scale genome-wide asso...

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Bibliografiska uppgifter
I publikationen:Am J Hum Genet
Huvudupphovsmän: Freund, Malika Kumar, Burch, Kathryn S., Shi, Huwenbo, Mancuso, Nicholas, Kichaev, Gleb, Garske, Kristina M., Pan, David Z., Miao, Zong, Mohlke, Karen L., Laakso, Markku, Pajukanta, Päivi, Pasaniuc, Bogdan, Arboleda, Valerie A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6174356/
https://ncbi.nlm.nih.gov/pubmed/30290150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2018.08.017
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