Rational Design and Screening of Peptide-Based Inhibitors of Heat Shock Factor 1 (HSF1)

Heat shock factor 1 (HSF1) is a stress-responsive transcription factor that regulates expression of protein chaperones and cell survival factors. In cancer, HSF1 plays a unique role, hijacking the normal stress response to drive a cancer-specific transcriptional program. These observations suggest t...

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Bibliographic Details
Published in:Bioorg Med Chem
Main Authors: Ran, Xu, Burchfiel, Eileen T., Dong, Bushu, Rettko, Nicholas J., Dunyak, Bryan M., Shao, Hao, Thiele, Dennis J., Gestwicki, Jason E.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6174099/
https://ncbi.nlm.nih.gov/pubmed/29661622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.04.018
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