Calpain-6 controls the fate of sarcoma stem cells by promoting autophagy and preventing senescence

Sarcomas are still unsolved therapeutic challenges. Cancer stem cells are believed to contribute to sarcoma development, but lack of specific markers prevents their characterization and targeting. Here, we show that calpain-6 expression is associated with cancer stem cell features. In mouse models o...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Andrique, Caroline, Morardet, Laetitia, Linares, Laetitia K., Cissé, Madi Y., Merle, Candice, Chibon, Frédéric, Provot, Sylvain, Haÿ, Eric, Ea, Hang-Korng, Cohen-Solal, Martine, Modrowski, Dominique
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6171816/
https://ncbi.nlm.nih.gov/pubmed/30185659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121225
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